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اسلاید 1 :

Bordetella pertussis Basics

• Aerobic, Gram negative coccobacillus
• Alcaligenaceae Family
• Specific to Humans
• Colonizes the respiratory tract

–Whooping Cough (Pertussis)

اسلاید 2 :

is a bacterium identified in 1900 by  Jules Bordet and Octave Gengou but isolated only in 1906 because of the development of a medium containing potatoes extract and rabbit blood

اسلاید 3 :

Estimated annual childhood deaths, 2002

Meningococcal  (< 1%)

rotavirus (16%)

pneumococcal (28%)

Hib (15%)

measles (21%)

pertussis (11%)

 yellow fever (1%)

diphtheria (<1%)

 polio (< 1%)

10.5 million deaths under 5 years of age

1.4 million  from diseases where vaccination is currently available

1.1 million from diseases where vaccines will be available by 2008

اسلاید 4 :

Pertussis in a vaccinated country vs a non vaccinated country

Low vaccine coverage

 *High morbidity and mortality in infants

 *Regular asymptomatic contacts throughout life

 *Unknown epidemiology in adults

High vaccine coverage

 *Low morbidity and mortality in infants

 *Few asymptomatic contacts throughout life

 *Increase in susceptible adolescents and adults

اسلاید 5 :

Why speaking about Pertussis?

• Iran pertussis incidence 2010 : 0.5/ 100000
• DTP3 coverage more than 95%

اسلاید 6 :

روند ميزان بروز سياه سرفه محتمل و پوشش واكسن ثلاث نوبت سوم
(جمهوري اسلامي ايران 1391-1370)

اسلاید 7 :

فراواني موارد محتمل سياه سرفه برحسب دانشگاه علوم پزشکی 1391

اسلاید 8 :

توزیع جغرافیایی موارد مثبت بیماری سیاه سرفه دركشور 1391

اسلاید 9 :

Infants

 The severity of pertussis and the rapidity of its progression in young infants is effected by a number of factors such as:

• the presence of transplacentally acquired maternal antibodies to B. pertussis,
• the infectious dose of bacteria that the infant receives,
• co-infection with respiratory

viruses and perhaps genetic

 factors related to the

pathogen or the infant.

اسلاید 10 :

• Short catarrhal period, longer convalescence period
• Cough,feeding abn, res distress,apnea,cyanosis, bradycardia, whoop uncommon,
• paroxysms and this may lead to apnea, gasp, hypoxia and occasionally seizures
• Initially the chest is clear on auscultation but in fatal cases B. pertussis pneumonia is always present.
• Co-infection with respiratory viruses (particularly RSV and adenoviruses) can confuse the diagnoses because of a bronchiolitic picture (air trapping and expiratory distress).